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Designing a patient-specific
cancer treatment involves many important
decisions. Understanding the role that floxuridine
can play in optimizing the treatment experience
requires a detailed look at its cellular
level and its dual mechanisms affecting
both RNA and DNA. Floxuridine works through
inhibiting the thymidylate synthase enzyme
which disrupts DNA replication. In addition,
it provides the critical sugars necessary
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Floxuridine offers an
improved rate of cellular penetration versus
5-FU. Inside cancer cells, floxuridine is
converted to 5-FU and FdUMP, which are both
active. Cancer patients who would typically
be treated with 5-FU can experience improved
outcomes because of floxuridine’s
unique effects on both RNA and DNA. Floxuridine
is currently being utilized in numerous
treatment protocols in combination with
other active agents for the treatment of
colorectal, pancreatic and gastric cancers.
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